iPSC和ESC Growth因子和细胞因子

诱导多能干细胞(iPSCs)和胚胎干细胞(ESCs)

In 2012, the Nobel prize for physiology or medicine was awarded for the discovery that adult somatic cells can be reverted to a pluripotent stem cell state using reprogramming factors. 从那时起, induced pluripotent stem cells (iPSCs) have become one of the most promising pathways for therapeutic applications. 

多能干细胞, 包括诱导多能干细胞和胚胎干细胞, 有先天的能力无限自我更新 和分化成任何细胞类型. This confers a unique advantage when compared to other cell therapies since the starting cells can be differentiated into any specific cell type required for the final therapy. 多能干细胞在分化之前也可以作为基因改造的画布. This enhances the targeted therapeutic benefit by yielding not only the desired phenotypic characteristics but also the genetic characteristics to maximize efficacy. 另外, 移植物抗宿主病(GvHD)的影响可以 减轻, 通过某些基因修改. 最后, ESCs和iPSCs可作为 生成DC的新细胞源, T细胞疗法, NK细胞和胰岛.

iPSC和ESC生长因子和细胞因子

FGF-2 更多信息访问eShop

转化生长因子-β1

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苯丙酸诺龙一

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表皮生长因子 更多信息访问eShop

il - 1β

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OSM

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自洽场

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房产申诉专员署

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FGF-2

CellGenix® 重组人成纤维细胞 生长因子2, 也 称为  bFGF) 是 无异种和 动物来源的无成分产品. 可促进间充质干细胞(MSCs)增殖. It in addition supports proliferation and 分化 of chondrocytes and supports propagation of undifferentiated pluripotent stem cells (PSCs). ​ 

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一般信息 

成纤维细胞生长因子-2 (FGF-2)是一种碱性成纤维细胞生长因子. It amongst others plays an important role in wound healing and tumor development by mediating the formation of new blood vessels.​ 

FGF-2 is used in the cell and gene therapy space for the expansion of bone marrow and adipose tissue derived MSCs. 

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转化生长因子-β1

CellGenix® Recombinant Human Transforming Growth Factor-beta 1 (转化生长因子-β1) is a xeno-free and animal-derived component-free product. 它能可靠地促进诱导多能干细胞(iPSC)的扩增, 胚胎干细胞, 间充质干细胞和调节性T细胞. 它还会刺激T细胞向treg细胞分化. CellGenix® rh 转化生长因子-β1在一个专门的无动物GMP设施中生产.​


一般信息

转化生长因子-β1 is a member of the growth factor beta superfamily and plays a role in various cellular functions like cell 分化, 增殖和凋亡. 它由大多数免疫细胞分泌,特别是与T细胞相互作用, B细胞, 巨噬细胞和单核细胞.​

转化生长因子-β1用于细胞和基因治疗空间,促进iPSC、ESC、MSC和Tregs的扩增.​

CellGenix® 重组人转化生长因子-β1是用人羊膜细胞(CAP)生产的®). 通过使用CAP® technology we are able to produce this difficult to express glyco-protein with authentic human post-translational modifications. 这些人类翻译后修饰是细菌表达所不能达到的.

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苯丙酸诺龙一

CellGenix® 重组人激活素A是一种无异种和动物来源的无成分产品. It reliably promotes definitive endoderm 分化 of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). 此外,它还维持着esc和iPSCs的未分化状态. ​
 

一般信息

激活素A属于转化生长因子β (TGF-β)超家族. 它调节多种生物功能, 包括细胞增殖, 分化, 细胞凋亡与创面修复.​

Activin A is used in the cell and gene therapy space to promote 分化 of ESCs and iPSCs into definitive endoderm, 用于多能干细胞(PSCs)的维持和自我更新.

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表皮生长因子

CellGenix® 重组人 表皮 生长 因子(表皮生长因子) 是一种 无异种和动物来源的无成分产品. 它 可靠地促进了间充质干细胞(MSCs)的扩增. It in addition promotes the 分化 of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs)-derived hepatoblasts. ​ 

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一般信息 

表皮生长因子是一种促进细胞生长、增殖和分化的生长因子. 它存在于各种各样的人体体液中 .​ 

表皮生长因子 is used in the cell and gene therapy space for the expansion of bone marrow and adipose tissue derived MSCs, 以及干细胞衍生肝细胞的生成. 

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il - 1β

CellGenix® 重组人白细胞介素-1β (il - 1β)是一种无异种和动物来源的无成分产品. 它能可靠地刺激未成熟树突细胞(dc)的成熟. 此外,它还能促进多能干细胞(PSCs)衍生巨核细胞的生成。.​

一般信息

il - 1β is a proinflammatory cytokine that is mainly produced by monocytes and activated macrophages as a proprotein. 炎症反应是由il - 1β介导的T细胞,自然杀伤细胞(NK细胞)和B细胞. 它诱导产生促炎细胞因子(IL-2, IL-3, IL-6)以及干扰素. 此外,il - 1β可调节不同亚型的人类树突状细胞因子的分泌.​

CellGenix® il - 1β被用于细胞和基因治疗空间,用于未成熟树突状细胞的体外成熟.

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OSM

CellGenix® 重组人肿瘤抑制素M (OSM)是一种无异种和动物来源的无成分产品. It promotes the 分化 of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) derived hepatoblasts into hepatocytes.​

一般信息

Oncostatin M (OSM) is a cytokine belonging to the interleukin-6 (IL-6) subfamily and it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. 它主要由T细胞和单核细胞产生. OSM在肝脏发育过程中起着重要作用, 造血作用, 和炎症, 也被证明与骨形成和骨吸收有关.

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自洽场

CellGenix® 重组人干细胞因子(自洽场)是一种无异种和动物来源的无成分产品. It reliably supports survival and 分化 of hematopoietic stem cells (HSCs) and progenitor cells as well as the 分化 of cord blood-derived CD34+ cells into natural killer cells (NK cells). It is also used to differentiate embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into megakaryocytes and T cells.​

一般信息

自洽场是一种由成纤维细胞和内皮细胞产生的细胞因子. 它在造血、精子发生和黑色素形成中起着重要的作用.​

自洽场被用于细胞和基因治疗领域,用于扩大造血干细胞用于移植.

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房产申诉专员署

CellGenix® 重组人血小板生成素(房产申诉专员署)是一种无异种和动物来源的无成分产品. It reliably supports the self-renewal and maintenance of hematopoietic stem cells (HSCs) as well as the 分化 of HSCs into natural killer cells (NK cells). It is also used to differentiate embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into megakaryocytes.​

一般信息

房产申诉专员署是肝脏和肾脏产生的一种糖蛋白激素. It regulates the production of platelets and stimulates the production and 分化 of megakaryocytes.​

房产申诉专员署被用于细胞和基因治疗空间,用于造血干细胞的体外扩增和分化.

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科技的笔记

旨在满足翻译研究的需要, our ‘preclinical grade’ 细胞因子 are ideal to allow for a seamless transition from preclinical development to the clinical stage. CellGenix® 临床前细胞因子和GMP细胞因子在GMP设施中相同的条件下产生, 使用相同的生产步骤和表达系统. 这确保了同等的产品质量和性能.​

The difference between both quality levels is that we offer a more comprehensive QC testing including tighter specifications and documentation for our GMP products. Our preclinical grade products therefore offer a cost-efficient alternative for the early development phase when safety and quality of ancillary materials have a lower priority.

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质量属性

临床前级

GMP级

不育性测试

是的

Ph. 欧元.

纯度

≥ 95%

≥ 97%

内毒素检测(除IL-2、IL-7、IL-15、IL-21和转化生长因子-β1外的所有细胞因子)

< 1000 EU/mg

≤50欧盟/毫克

内毒素检测(IL-2、IL-7、IL-15、IL-21)

< 25 EU/mg

≤25个欧盟/毫克

内毒素测试(TGF -β1)

< 25 EU/mg

≤10个欧盟/毫克

十大靠谱网赌平台CellGenix® is the only supplier with a preclinical grade that can be replaced directly with the corresponding product at GMP grade in clinical and commercial manufacturing use.​

质量 and consistency of critical ancillary materials are directly linked to the clinical and commercial success of a therapy. Several years of proven batch-to-batch consistency across the preclinical and GMP 细胞因子 range demonstrate the high quality, 安全可靠的CellGenix® 细胞因子.

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Ancillary materials derived from biological origin can introduce risks to the process and final ATMP product, 包括病毒的传播.​

使用动物来源的无成分细胞因子:

  • 确保ATMP的最大安全性, 十大靠谱网赌平台的细胞因子产品中没有动物或人类来源的成分. ​
  • 减少与动物衍生成分相关的变量.​
  • 使耗时昂贵的病毒安全性研究过时, 从而带来显著的经济效益.​

十大靠谱网赌平台的绝大多数细胞因子是在专门的无动物设施中产生的(ADCF 2级). 这些细胞因子从未接触过动物成分或副产品.​

Very few 细胞因子 produced in the segregated animal-derived components (ADC) production area require either the use of ADC in the production process or a human expression system to allow proper functional expression (ADCF Level 1). 为确保最大程度的安全性,十大靠谱网赌平台提供病毒和朊病毒安全性的书面证据.​

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CellGenix® 细胞因子被冻干,使其在大范围的温度下保持稳定. 产品在环境温度下以十大靠谱网赌平台的标准包装交付.

To ensure that the product quality is not compromised during shipment at ambient temperatures we have put a validated shipment procedure in place. 作为这个过程的一部分, 十大靠谱网赌平台实施了特殊的温度控制措施,并进行了运输稳定性研究.

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